I am back from my little escape to Rome! It was an amazing weekend, filled with wonderful sights. We must have walked the entire city in three days. We never returned to our hotel until the night, just to sleep and recharge the batteries!
Trastevere was a wonderful suggestion! Thank you, aidance, for mentioning it to me. We loved the little streets and alleys. We had a great meal in a little trattoria there too. And walking over to the little island was also fun.

I loved the Galleria Borghese--the Bernini statues are incredibly awe-inspiring. The Colosseum, the Forum, the Pantheon, the many, many piazzas and churches we went to...wow! It was wonderful.
Seeing the Sistine Chapel again was also a highlight. It is gorgeous.

All in all, Rome is a magnificent city. Thank you for your ideas and suggestions. Ciau!