Good point about having small euro bills handy. If you are just arriving in Spain, it is also good to have some small change for tips, etc. by breaking one of the bills at a newstand or cafeteria. I've used several ATM's at BBVA bank facilities (including the one at Barajas airport) & when I withdraw 300 euros, I've been given 4 fifties & 5 twenties in every case.