I don't remember it being that bad (but then I was probably asleep most of the ride!)....but in my opinion you will be hard pressed to find many "straight shots" anywhere in southern spain. I was on quite a few cury bus rides last semester, but NOTHING can even compare to the ride up to the Alpujarras...I don't normally get car sick, but I needed a good nap to recover from that one
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If you do take the bus, try to get seats in the front. I found that most bus companies seat you in the order that you buy the tickets...so maybe buy them early and you can request the front.
Good Luck!! You will love Granada!
Kelly